| 1 | 360* | HRC Came & LM Reece | Derbyshire v Glamorgan | 2023 | f61668 |
| 2 | 417 | KJ Barnett & TA Tweats | Derbyshire v Yorkshire | 1997 | f43249 |
| 3 | 351 | TJ Haines & CA Pujara | Sussex v Derbyshire | 2022 | f60821 |
| 4 | 316 | U Afzaal & JE Morris | Nottinghamshire v Derbyshire | 2001 | f45954 |
| 5 | 273 | MK Andersson & LM Reece | Derbyshire v Worcestershire | 2026 | f63537 |
| 6 | 372* | KP Pietersen & JE Morris | Nottinghamshire v Derbyshire | 2001 | f45954 |
| 7 | 258 | MP Dowman & DG Cork | Derbyshire v Durham | 2000 | f45249 |
| 8 | 170 | AG Botha & AKD Gray | Derbyshire v Somerset | 2005 | f48763 |
| 9 | 191 | HJH Brookes & WSA Williams | Gloucestershire v Derbyshire | 2026 | f63573 |
| 10 | 121 | JAR Harris & WT Owen | Glamorgan v Derbyshire | 2011 | f53284 |