| 126* | M Klinger | Gloucestershire v Essex | 2015 | tt4926 |
| 126* | MNK Fernando | Sri Lanka Cricket Development XI v Gloucestershire | 2022 | tt10859 |
| 123 | IA Cockbain | Gloucestershire v Middlesex | 2018 | tt7109 |
| 111* | LJ Wright | Sussex v Gloucestershire | 2015 | tt4991 |
| 108* | M Klinger | Gloucestershire v Worcestershire | 2013 | tt3663 |
| 104* | M Klinger | Gloucestershire v Glamorgan | 2015 | tt4953 |
| 101* | JA Rudolph | Glamorgan v Gloucestershire | 2015 | tt4953 |
| 101* | M Klinger | Gloucestershire v Hampshire | 2017 | tt6366 |
| 100* | RG Sharma | India v England | 2018 | tt7026 |