| 212 | DS Smith | Windward Islands v Guyana | 2008/09 | f51310 |
| 204 | CH Gayle | West Indies v New Zealand | 2002 | f46664 |
| 193 | DS Smith | Windward Islands v Guyana | 2009/10 | f52305 |
| 192 | KS Melius | Windward Islands v Trinidad and Tobago | 2022/23 | f61416 |
| 189* | LR Johnson | Guyana v Windward Islands | 2019/20 | f60015 |
| 185* | DS Smith | Windward Islands v Leeward Islands | 2017/18 | f58180 |
| 182* | JE Root | England v West Indies | 2014/15 | f56360 |
| 154 | DS Smith | Windward Islands v West Indies B | 2003/04 | f47808 |
| 147* | DS Smith | Windward Islands v Guyana | 2019/20 | f60015 |
| 145 | DS Smith | Windward Islands v Leeward Islands | 2014/15 | f55945 |
| 141 | AS Athanaze | Windward Islands v Guyana | 2022/23 | f61428 |
| 135 | NE Bonner | Jamaica v Windward Islands | 2019/20 | f60095 |
| 128 | KAR Hodge | Windward Islands v Trinidad and Tobago | 2017/18 | f58439 |
| 125 | CAK Walton | Jamaica v Windward Islands | 2018/19 | f59262 |
| 124 | DS Smith | Windward Islands v Jamaica | 2018/19 | f59262 |
| 122 | RR Sarwan | Guyana v England A | 2000/01 | f45568 |
| 118 | IJ Ward | England A v Guyana | 2000/01 | f45568 |
| 116* | ADR Campbell | Zimbabweans v West Indies Board XI | 1999/00 | f45032 |
| 116 | RR Sarwan | Guyana v Windward Islands | 2009/10 | f52305 |
| 116 | KC Brathwaite | West Indies v England | 2014/15 | f56360 |
| 115 | SC Joseph | West Indies Board XI v Bangladeshis | 2004 | f47988 |
| 114* | P Palmer | Jamaica v Windward Islands | 2019/20 | f60095 |
| 107 | SB Styris | New Zealand v West Indies | 2002 | f46664 |
| 107 | CD Barnwell | Guyana v Windward Islands | 2019/20 | f60015 |
| 105 | JR Murray | Windward Islands v Jamaica | 2001/02 | f46320 |
| 105* | KA Hope | Trinidad and Tobago v Windward Islands | 2016/17 | f57801 |
| 104* | JP Crawley | England A v Guyana | 2000/01 | f45568 |
| 104 | KO Otieno | Kenya v Jamaica | 2003/04 | f47765 |
| 104 | O Peters | Leeward Islands v Windward Islands | 2014/15 | f55945 |
| 103 | JR Murray | Windward Islands v West Indies B | 2001/02 | f46424 |
| 103* | DR Smith | West Indies Board XI v Bangladeshis | 2004 | f47988 |
| 103 | MN Samuels | West Indies v England | 2014/15 | f56360 |
| 102* | Y Cariah | Trinidad and Tobago v Windward Islands | 2016/17 | f57801 |
| 100 | DJ Bravo | West Indies Board XI v Bangladeshis | 2004 | f47988 |
| 100* | KAR Hodge | Windward Islands v Guyana | 2019/20 | f60015 |
| 100* | JM Da Silva | West Indies v England | 2021/22 | f60796 |