| 135 | Saleem Elahi | Pakistan v South Africa | 2002/03 | o1915 |
| 130* | DA Miller | South Africa v West Indies | 2014/15 | o3591 |
| 125 | HH Gibbs | South Africa v West Indies | 1998/99 | o1397 |
| 121* | JH Kallis | South Africa v West Indies | 2007/08 | o2666 |
| 119* | T de Zorzi | South Africa v India | 2023/24 | o4714 |
| 115* | ME Waugh | Australia v South Africa | 1996/97 | o1187 |
| 115 | RG Sharma | India v South Africa | 2017/18 | o3976 |
| 112 | Abdul Razzaq | Pakistan v South Africa | 2002/03 | o1915 |
| 110 | HH Gibbs | South Africa v Australia | 2008/09 | o2840 |
| 108* | HM Amla | South Africa v Pakistan | 2018/19 | o4080 |
| 105 | GC Smith | South Africa v England | 2004/05 | o2221 |
| 102 | Ahmed Shehzad | Pakistan v South Africa | 2013/14 | o3440 |