| 200 | MB van Buuren | Gauteng v Western Province | 2018/19 | a27008 |
| 193 | Fakhar Zaman | Pakistan v South Africa | 2020/21 | a28385 |
| 186 | EJ Barlow | EJ Barlow's XI v RG Pollock's XI | 1969/70 | a291 |
| 183 | AK Markram | Titans v Lions | 2016/17 | a25336 |
| 175 | HH Gibbs | South Africa v Australia | 2005/06 | a17325 |
| 175 | AK Markram | South Africa v Netherlands | 2023 | a29930 |
| 169 | RG Pollock | RG Pollock's XI v EJ Barlow's XI | 1969/70 | a291 |
| 164 | RT Ponting | Australia v South Africa | 2005/06 | a17325 |
| 153* | HM Amla | South Africa v West Indies | 2014/15 | a23913 |
| 152* | CH Gayle | West Indies v South Africa | 2003/04 | a15705 |