| 6-19 | HK Olonga | Zimbabwe v England | 1999/00 | o1551 |
| 6-22 | M Ntini | South Africa v Australia | 2005/06 | o2344 |
| 5-21 | N Boje | South Africa v Australia | 2001/02 | o1827 |
| 5-25 | L Klusener | South Africa v Pakistan | 1997/98 | o1326 |
| 5-32 | WJ Cronje | South Africa v India | 1992/93 | o770 |
| 5-37 | M Ntini | South Africa v Sri Lanka | 2000/01 | o1668 |
| 5-41 | JH Kallis | South Africa v Pakistan | 2002/03 | o1923 |
| 5-48 | WD Parnell | South Africa v England | 2009/10 | o2930 |
| 4-16 | CA Walsh | West Indies v Pakistan | 1992/93 | o808 |
| 4-21 | CK Langeveldt | South Africa v Kenya | 2001/02 | o1763 |
| 4-22 | WPUJC Vaas | Sri Lanka v West Indies | 2002/03 | o1972 |
| 4-23 | K Yadav | India v South Africa | 2017/18 | o3971 |
| 4-26 | SM Pollock | South Africa v India | 2006/07 | o2449 |
| 4-28 | TM Odoyo | Kenya v Canada | 2002/03 | o1952 |
| 4-29 | JM Anderson | England v Pakistan | 2002/03 | o1961 |
| 4-34 | SM Pollock | South Africa v England | 1995/96 | o1033 |
| 4-34 | JE Taylor | West Indies v South Africa | 2007/08 | o2664 |
| 4-34 | MG Johnson | Australia v South Africa | 2008/09 | o2839 |
| 4-36 | M Morkel | South Africa v West Indies | 2007/08 | o2664 |
| 4-41 | Waqar Younis | Pakistan v South Africa | 2002/03 | o1923 |
| 4-42 | EO Simons | South Africa v Pakistan | 1994/95 | o970 |
| 4-44 | KD Mills | New Zealand v South Africa | 2005/06 | o2288 |
| 4-46 | YS Chahal | India v South Africa | 2017/18 | o3971 |
| 4-47 | CR Matthews | South Africa v Australia | 1993/94 | o902 |
| 4-47 | Shaheen Shah Afridi | Pakistan v South Africa | 2024/25 | o4818 |
| 4-58 | WD Parnell | South Africa v Sri Lanka | 2016/17 | o3833 |
| 4-68 | Saqlain Mushtaq | Pakistan v South Africa | 2002/03 | o1923 |
| 4-71 | SCJ Broad | England v South Africa | 2009/10 | o2930 |
| 4-72 | KT Maphaka | South Africa v Pakistan | 2024/25 | o4818 |