| 117* | CS Delport | Islamabad United v Lahore Qalandars | 2018/19 | tt7764 |
| 117 | MJ Guptill | Quetta Gladiators v Karachi Kings | 2022/23 | tt11990 |
| 116 | JJ Roy | Quetta Gladiators v Lahore Qalandars | 2021/22 | tt10545 |
| 115 | Imran Farhat | Lahore Eagles v Multan Tigers | 2005/06 | tt354 |
| 111* | Zubair Ahmed | Quetta Bears v Larkana Bulls | 2014/15 | tt4519 |
| 110* | Babar Azam | Pakistan v England | 2022/23 | tt11409 |
| 109 | Khurram Manzoor | Karachi Zebras v Multan Tigers | 2014/15 | tt4517 |
| 109* | Sahibzada Farhan | Peshawar v Larkana | 2023/24 | tt12930 |
| 107 | Yasir Khan | Rawalpindi v Federally Administered Tribal Areas | 2023/24 | tt12951 |
| 106 | Fakhar Zaman | Lahore Qalandars v Karachi Kings | 2021/22 | tt10527 |
| 106* | Usman Khan | Multan Sultans v Karachi Kings | 2023/24 | tt13292 |
| 105 | Sharjeel Khan | Karachi Kings v Islamabad United | 2020/21 | tt9405 |
| 105* | Mohammad Rizwan | Multan Sultans v Karachi Kings | 2024/25 | tt15006 |
| 101* | Yasir Hameed | Abbottabad Falcons v Quetta Bears | 2011/12 | tt2388 |
| 101 | Kamran Akmal | Peshawar Zalmi v Quetta Gladiators | 2019/20 | tt8800 |
| 101 | JM Vince | Karachi Kings v Multan Sultans | 2024/25 | tt15006 |
| 100 | Mohammad Hafeez | Faisalabad Wolves v Lahore Lions | 2009/10 | tt1592 |
| 100* | Awais Zia | Rawalpindi Rams v Federally Administered Tribal Areas Cheetas | 2014/15 | tt4515 |
| 100* | Mukhtar Ahmed | Sialkot Stallions v Karachi Dolphins | 2014/15 | tt4535 |