| 6 | ATW Grout | South Africa v Australia | 1957/58 | t444 |
| 6 | DT Lindsay | Australia v South Africa | 1966/67 | t611 |
| 6 | RC Russell | South Africa v England | 1995/96 | t1315 |
| 6 | AB de Villiers | Pakistan v South Africa | 2012/13 | t2072 |
| 6 | JM Bairstow | South Africa v England | 2015/16 | t2199 |
| 5 | HB Taber | South Africa v Australia | 1966/67 | t611 |
| 5 | RC Russell | South Africa v England | 1995/96 | t1315 |
| 5 | IA Healy | South Africa v Australia | 1996/97 | t1356 |
| 5 | MV Boucher | England v South Africa | 1999/00 | t1471 |
| 5 | MV Boucher | Australia v South Africa | 2005/06 | t1795 |
| 5 | AB de Villiers | Pakistan v South Africa | 2012/13 | t2072 |
| 5 | Q de Kock | India v South Africa | 2017/18 | t2294 |
| 5 | Sarfraz Ahmed | South Africa v Pakistan | 2018/19 | t2341 |
| 5 | Sarfraz Ahmed | South Africa v Pakistan | 2018/19 | t2341 |
| 5 | Q de Kock | Sri Lanka v South Africa | 2020/21 | t2401 |